肥胖对患有扩散型大B细胞淋巴瘤的患者的影响,接受化学抗原受体T细胞治疗
Jia Yi Tan1, Yong Hao Yeo2, Hermon Kha Kin Wong3
1Department of Internal Medicine, New York Medical College at Saint Michael's Medical Center, Newark, New Jersey, USA, jiayitanmd@gmail.com.
Oncology
|June 15, 2025
概括
肥胖与用于扩散大B细胞淋巴瘤 (DLBCL) 的仿真抗原受体 (CAR) T细胞疗法后的更高的早期死亡率和非家庭出院有关. 对接受CAR-T治疗的肥胖患者需要量身定制的策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 肥胖是常规癌症治疗中不良结果的已知危险因素.
- 肥胖对仿真抗原受体 (CAR) T细胞治疗扩散性大B细胞淋巴瘤 (DLBCL) 的影响尚不清楚.
- 这项研究调查了接受CAR-T治疗的DLBCL患者肥胖和住院结果之间的关联.
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
相关概念视频
01:27Tumor Immunotherapy
675
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
675
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:24Obesity
631
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
631