基于农业生物废弃物的消毒剂配方减轻了耐药性医院病原体
Srividhya Krishnan1, Ponnusami Venkatachalam2, Pazhanisamy Kavitha3
1Biofilm Biology Laboratory, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613401, India; Biomass, Bioenergy and Bioproducts Laboratory, 3Centre for Bioenergy, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613401, India.
Microbial pathogenesis
|June 15, 2025
概括
这项研究开发了一个环保的消毒剂从小麦粉热解水阶段. 这种新型消毒剂有效杀死医院病原体,破坏生物膜,为传统产品提供可持续的替代品.
科学领域:
- 生物质价值化 生物质价值化
- 绿色化学是一种绿色化学.
- 环境微生物学环境微生物学
背景情况:
- 医院感染是一个主要问题,表面充当病原体储存库.
- 传统的消毒剂具有显著的环境缺点,包括高碳足迹和有毒排放.
- 迫切需要可持续,环保的消毒替代品.
研究的目的:
- 从小麦生物质热解的水阶段制备一种新型消毒剂.
- 评估这种消毒剂对关键医院病原体及其生物膜的疗效.
- 评估开发的消毒剂对环境的安全性.
主要方法:
- 小麦的热解以获得水相 (AQ).
- 使用系数测试对抗抗菌素耐药性黄金葡萄球菌,宝曼菌和黄菌的抗菌疗效测试.
- 使用CDC生物膜反应堆模型在不钢316优惠券上的生物膜破坏评估.
- 活/死光染色用于生物膜活力.
- 用于生态毒性评估的地毒性测定.
主要成果:
- 这种基于AQ的消毒剂显示了对浮游生物和共同培养的医院病原体的显著杀死率.
- 消毒剂的醇系数大于1,表明了良好的疗效.
- 它有效地破坏了成熟的多种生物膜,在生物膜细胞中实现了6-log的减少.
- 在经过处理的生物膜中,活/死染色证实了细胞死亡.
- 使用土进行的初步毒性评估表明,土具有有利的环境特征.
结论:
- 小麦热解水相可以成功地转化为有效的消毒剂.
- 这种绿色消毒剂对医院关键病原体及其生物膜具有强烈的活性.
- 该配方为传统消毒剂提供了一个有希望的,可持续的替代品,利用农业废物.
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