肠道微生物群的营养获取:对瘤免疫力的影响
Yusha Wang1, Jing Huang2, Huan Tong1
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Seminars in cancer biology
|June 15, 2025
概括
肠道微生物群通过其代谢物影响结肠直肠癌 (CRC). 通过饮食或益生菌调节肠道生态系统,为CRC预防和治疗提供了新的策略.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在结直肠癌 (CRC) 的发展,进展和治疗反应中发挥着关键作用.
- 微生物组成受到饮食和宿主生理学等环境因素的影响.
- 细菌的新陈代谢产生各种化合物,包括短链脂肪酸 (SCFA) 和胆汁酸 (BA).
研究的目的:
- 审查肠道微生物代谢在CRC中的作用.
- 讨论微生物代谢产物的免疫调节作用.
- 探索针对微生物群的策略,以改善CRC治疗.
主要方法:
- 关于肠道微生物群和CRC的当前研究的文献综述.
- 分析微生物营养代谢及其对宿主免疫力的影响.
- 探索针对肠道微生物组的治疗干预措施.
主要成果:
- 微生物代谢物可以根据类型,度和宿主环境促进或抑制瘤生长.
- 诸如高纤维饮食,益生菌,益生菌和便微生物群移植 (FMT) 等干预措施可以改变肠道微生物群.
- 这些干预措施在增强抗瘤免疫反应和提高CRC治疗疗效方面表现有前途.
结论:
- 肠道微生物群及其代谢产品是结直肠癌的关键参与者.
- 准肠道微生物组为新的CRC预防和治疗策略提供了一个有希望的途径.
- 进一步了解宿主-微生物相互作用可以打开新的治疗机会.
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