坚果摄入对成年人肠道微生物组合和肠道功能的影响:系统性审查和元分析
Matthew Snelson1, Jessica R Biesiekierski2, Susanna Chen3
1Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, Victoria, Australia; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia.
Advances in nutrition (Bethesda, Md.)
|June 15, 2025
概括
坚果消费对肠道健康有适度的影响,主要是增加酸水平. 然而,研究中的显著异质性限制了关于肠道微生物群组成和功能的坚定结论.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 坚果消费与降低慢性疾病风险有关,可能是通过肠道微生物群调节.
- 坚果对肠道微生物群和功能的全面影响仍然被低估.
研究的目的:
- 系统地审查临床试验,评估坚果对成年人肠道微生物群组成,代谢物,功能和症状的影响.
- 评估各种坚果对肠道健康指标的影响.
主要方法:
- 按照PRISMA指南进行系统审查,包括28项临床试验.
- 对便水分,pH值,肠道透性和短链脂肪酸 (SCFA) 度进行的元分析.
- 评估微生物群多样性,细菌丰富度和胃肠道症状.
主要成果:
- 大多数研究都没有发现总体微生物群多样性或分类组合的显著变化.
- 对便 propionate 度观察到积极影响;对便 pH 或肠道透性没有影响.
- 观察到对便水分的不利影响,对Bifidobacterium物种的结果不一.
结论:
- 坚果对肠道健康产生适度的影响,对微生物群组成的显著改变的证据有限.
- 研究中的大量异质性阻碍了关于坚果消费和肠道健康的最终结论.
- 需要进一步的研究来澄清坚果对肠道健康的具体机制和益处.
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