在体外受精 (IVF) 中抗结核治疗的作用
Kaberi Banerjee1, Bhavana Singla1, Priyanka Verma2
1Advance Fetility and Gynaecology Centre, New Delhi, India.
The Indian journal of tuberculosis
|June 15, 2025
概括
抗结核治疗 (ATT) 显示出改善试管婴儿成功率的前景,对于患有薄膜子宫内膜和反复植入失败的妇女来说. 在一项回顾性研究中,这种治疗增强了子宫内膜厚度和临床怀孕率.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 精细的子宫内膜,反复的试管婴儿失败和反复流产是不孕症治疗的重大挑战.
- 越来越多地认识到亚临床感染 (包括结核病) 在子宫内膜受体性方面的作用.
研究的目的:
- 评估抗结核治疗 (ATT) 在接受体外受精 (IVF) 并且具有特定不孕因素的妇女的疗效.
- 评估ATT对子宫内膜厚度,怀孕率和临床怀孕率的影响.
主要方法:
- 追溯分析45名女性的子宫内膜薄,有反复试管婴儿失败的历史,或反复流产.
- 在生育治疗之前,给予6个月的ATT疗法 (Akt 4 Kit,其次是AKT 2).
- 计划在子宫内膜厚度超过8毫米时进行冷胚胎移植.
主要成果:
- 观察到68.8%的显著怀孕率和64.4%的临床怀孕率.
- ATT显示子宫内膜厚度有所改善,导致成功的胚胎植入.
- 在人口变量,卵子储备,精子参数或胚胎质量方面没有发现显著差异.
结论:
- 抗结核治疗 (ATT) 在改善治疗不响应药物的薄子宫内膜,反复的试管婴儿失败或反复流产的患者的试管婴儿结果方面发挥着重要作用.
- ATT对子宫内膜厚度,整体怀孕率和试管婴儿中临床怀孕率产生积极影响.
- 需要进一步的大规模研究来证实这些发现.
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