医疗数字双胞胎:实现精准医学和医疗人工智能
Christoph Sadée1, Stefano Testa2, Thomas Barba3
1Stanford Center for Biomedical Informatics Research, Department of Medicine, Stanford, CA, USA.
The Lancet. Digital health
|June 15, 2025
概括
医疗数字双胞胎,虚拟患者副本,在没有明确的定义的情况下出现. 本文概述了五个关键组件和支持技术,用于其在医疗保健中的临床采用.
科学领域:
- 卫生政策 卫生政策
- 医疗信息学 医疗信息学
- 计算生物学 计算生物学
背景情况:
- 数字双胞胎的概念起源于工程领域,正在医学领域获得引力.
- 对医疗数字双胞胎的基本组成部分缺乏共识,阻碍了进步.
- 对医疗数字双胞胎的现有热情正在超过对其结构和功能的清晰理解.
研究的目的:
- 定义和概述医疗数字双胞胎的基本组成部分.
- 探索启用技术及其在医疗数字双胞胎临床采用中的作用.
- 为指导医疗数字双胞胎的未来开发和实施提供一个框架.
主要方法:
- 在医疗背景下对数字双胞胎概念的评估.
- 确定和定义五个关键组件:患者,数据连接,患者-in-silico,接口和双同步.
- 分析支持技术,如多式联运数据,人工智能 (AI) 和机械建模.
主要成果:
- 一个针对医疗数字双胞胎提出的五个组成部分的框架.
- 讨论多式联络数据,人工智能和机械模型如何促进临床采用.
- 瘤学和糖尿病方面的例子说明了潜在的应用.
- 强调人工智能和机械模型的协同作用,以提高性能.
- 数字双胞胎在医学中支持大型语言模型的潜力.
结论:
- 医疗数字双胞胎需要一个标准化的框架来有效开发和实施.
- 整合人工智能和机械模型提供了一种强大的方法来克服个人的局限性.
- 该框架旨在指导科学家,临床医生和决策者将医疗数字双胞胎从理论转化为实践.
- 医疗数字双胞胎在解决复杂的医疗保健挑战方面具有重大潜力.
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