在健康的儿科人口中补充维生素D
David Gonzalez Jiménez1, Juan Rodríguez Delgado2, Cristina Campoy3
1Comité de Nutrición y Lactancia Materna de la AEP, Madrid, Spain; Área de Gestión Clínica de la Infancia y Adolescencia, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
Anales de pediatria
|June 15, 2025
概括
适用于健康儿童的万能维生素D补充剂对婴儿的骨健康有有限的益处. 对于年长的儿童,维生素D可能会降低呼吸道感染的风险,但建议个性化剂量.
科学领域:
- 儿科 儿科 儿科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 对儿童来说,广泛推服用维生素D补充剂.
- 目前的指导方针各不相同,需要对没有危险因素的健康儿童进行证据审查.
- 了解维生素D的疗效对于优化儿科健康建议至关重要.
研究的目的:
- 评估关于普遍维生素D补充剂在没有风险因素的健康儿童中有效性的科学证据.
- 提出关于儿童群体维生素D补充剂的临床实践指南的更新建议.
主要方法:
- 进行了对文献的范围审查.
- PubMed搜索了过去15年发表的英语或西班牙语文章,使用MeSH术语对维生素D和补充剂进行了搜索.
- 从最初的2133.3人中选择了22篇文章.
主要成果:
- 在1岁以下的婴儿中,每天400 IU的维生素D改善了基醇水平,但并没有始终显示改善骨健康.
- 在1岁以上的儿童中,低二醇水平 (<35 ng/mL),每天400-800 IU的维生素D补充剂降低了呼吸道感染的风险.
- 没有证据支持维生素D补充剂减少其他感染或为儿童提供骨外益处.
结论:
- 目前的指导方针建议母乳养的婴儿或那些无法通过配方奶粉摄入维生素D的婴儿每天摄入400 IU.
- 对于1岁以上的儿童,维生素D补充剂应根据具体需要和基醇水平进行个性化.
- 可能需要进一步的研究来澄清维生素D在儿童群体中的长期益处和最佳剂量策略.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.8K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.8K
01:25Role of Vitamins in Maintaining Bone Health
3.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.7K
01:22Connective Tissue Cell Types
3.5K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.5K
01:30Vitamins
1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K
01:31Essential Minerals for Bone Health
4.5K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.5K
01:28Chronic Kidney Disease III: Interprofessional Care
87
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
87