Glioportal:一个全面的转录基因资源,揭示了质母细胞瘤中联体介导的介质细胞过渡
Qing You Pang1, Wisna Novera1, Lynnette Wei Hsien Koh1
1Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute, Singapore.
Neuro-oncology
|June 15, 2025
概括
质母细胞瘤 (GBM) 的可塑性是由像TNF这样的髓质母细胞衍生联体驱动的,这些联体促进了侵入性. 准配体受体相互作用,特别是TNFRSF1A,为GBM提供了一个有前途的治疗策略.
科学领域:
- 神经瘤学神经瘤学
- 癌症生物学 癌症生物学
- 基因组学就是基因组学.
背景情况:
- 质母细胞瘤 (GBM) 表现出分子异质性和微环境调节的细胞可塑性,这有助于其攻击性.
- 驱动这些复杂的GBM机制的因果因素的经验验证是有限的.
- 格利波塔尔 (Glioportal) 是一家拥有临床前模型和分子数据的GBM生物库,为精密治疗研究而建立.
研究的目的:
- 调查质母细胞瘤 (GBM) 细胞可塑性的分子驱动因素,并确定治疗漏洞.
- 利用Glioportal资源进行GBM精密疗法的基础和转化研究.
主要方法:
- 多omics分析 (批量转录组,单细胞解卷) 以确定GBM亚型和调控途径.
- 在体外验证使用遗传追踪,基因沉默和基于细胞的测试 (入侵,迁移,抑制剂研究).
- 在体内使用正位异种移植进行概念验证,并通过免疫组织化学评估临床相关性.
主要成果:
- 在GBM中,STAT3和NF-κB通路对于介质细胞的身份和骨髓质诱导的可塑性至关重要.
- 瘤坏死因子 (TNF) 促进介质细胞的适应和侵入性,而TNFRSF1A则对抗这种作用.
- 抑制TNFRSF1A显著改善了体内生存率.
结论:
- Glioportal 作为一种在分子分层 GBM 中识别治疗点的资源.
- 由于GBM依赖于骨髓系衍生的连接体来对介质细胞的特征产生影响,这对治疗反应和复发有影响.
- 向瘤生态系统中的配体受体相互作用是GBM的潜在治疗策略.
相关概念视频
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...