自闭症谱系障碍中内分泌系统的改变:系统性审查和元分析
Xinlei Jia1, Shumin Gao2, Xiaotong Liu1
1School of Nursing, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
概括
自闭症谱系障碍 (ASD) 与内分泌系统 (ECS) 失调有关. 这项元分析在ASD动物模型和人类中发现了较低的安纳米德 (AEA) 水平,并在模型的特定大脑区域中降低了2-阿拉基多诺伊尔糖醇 (2-AG).
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 生物化学 生化学
背景情况:
- 内分泌大麻素系统 (ECS) 在神经功能中起着至关重要的作用.
- 自闭症谱系障碍 (ASD) 的病理生理学与ECS的变化有关.
研究的目的:
- 在ASD中对内分泌大麻素系统调节失调进行元分析.
- 在ASD动物模型中系统地审查ECS变化的影响.
主要方法:
- 16项动物研究和5项人类研究的元分析和系统审查.
- 对安纳米德 (AEA) 和2-阿拉基多诺伊尔糖醇 (2-AG) 水平的定量分析.
- 包含的研究发现的叙述综合.
主要成果:
- 在ASD动物模型中,海马AEA水平显著下降 (SMD = -1.06).
- 在ASD患者的血液AEA水平显著下降 (SMD = -0.79).
- 在ASD动物模型中,前额叶皮层2-AG水平显著下降 (SMD = -1.00),具有很高的异质性.
结论:
- 电脑神经系统的失调,特别是AEA和2-AG水平的降低,与ASD有关.
- 增加的AEA和2-AG可能会改善动物模型中的ASD类症状,具有区域和性别依赖的影响.
- 需要进一步的研究,以探索特异性区域和性别相关的内分泌素在ASD的机制.
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