通过CAP芯片进行RONS的流体操纵支持的多重剂量输送,以提高剂量优化效果
Fang Wang1,2,3, Liangyu Zhou4, Wei Guo1,5
1Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.
Microsystems & nanoengineering
|June 15, 2025
概括
这项研究引入了一种新的冷大气等离子体 (CAP) 装置,用于有效治疗癌症和伤口. 它在一次暴露中提供多个剂量,优化治疗和理解反应性物种作用.
科学领域:
- 生物医学工程 生物医学工程
- 等离子体物理学的物理学
- 在瘤学瘤学.
背景情况:
- 冷大气等离子体 (CAP) 使用活性氧和物种 (RONS) 治疗癌症和感染.
- 精确的剂量输送对于有效的CAP治疗至关重要,但目前的设备仅限于单样,单剂量治疗.
- 优化CAP剂量是具有挑战性的,因为无法同时测试多个条件.
研究的目的:
- 开发一种新的CAP交付系统,使"一次暴露,多剂量"治疗成为可能.
- 为了促进治疗应用的最佳CAP剂量的有效选.
- 研究短期和长期RONS在CAP生物效应中的不同作用.
主要方法:
- 设计了一种新的CAP装置,通过编程的流通道分发料气体,从而产生多样化的等离子体流.
- 该设备在单次曝光中向多个样品提供多次,流量变化的剂量.
- 气体流速被操纵以控制特定短寿命反应物种的产生.
主要成果:
- 开发的设备成功地同时给16个样本注射了三个不同的剂量.
- 确定了优化的CAP剂量,以有效地根除Huh7肝癌细胞和 Staphylococcus aureus 细菌在一次暴露中.
- 通过操纵气体流量来实现短期反应性物种的向生成,从而使RONS角色脱而出.
结论:
- "一次暴露,多次剂量"策略显著提高了CAP剂量优化的实验效率.
- 这种方法为短期与长期RONS.的生物功能机制提供了关键的见解.
- 使用流体控制的多重剂量治疗有望加速先进的CAP设备和疗法的开发.
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