维生素D水平与左心室心肌功能之间的相关性通过斑点跟踪心电回声学在β-thalassemia主要儿童中证明
Eman Gamal Abdelrahman1, Ahmed Mahmoud Ezzat1, Lina Abdelhady Mohammed2
1Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt.
European journal of pediatrics
|June 15, 2025
概括
维生素D缺乏在患有β-thalassemia major (β-TM) 的儿童中显著损害心脏功能. 补充维生素D有效改善了心脏参数,突出显示了在这些患者中保持足够水平的重要性.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 大型β-thalassemia (β-TM) 经常导致心脏功能障碍,这是主要的死亡原因,主要是由心脏铁过载引起的.
- 维生素D缺乏是β-TM的常见并发症,可能会加剧心脏功能障碍,而不依赖于铁过载.
- 维生素D补充正在作为一种治疗策略来改善β-TM患者的心脏功能.
研究的目的:
- 调查β-TM儿童维生素D水平与左心室 (LV) 功能之间的关联.
- 评估维生素D补充剂对常规心声学和斑点跟踪心声学 (STE) 评估的心脏参数的影响.
主要方法:
- 75名患有β-TM的儿童接受了维生素D水平的评估,常规心声学和STE.
- 患有维生素D缺乏/不足 (<30 ng/ml) 的患者每天接受维生素D补充剂 (4000-5000 IU).
- 在达到正常维生素D水平后,心脏功能被重新评估.
主要成果:
- 维生素D不足 (81.3%) 和缺乏 (18.7%) 在研究队列中非常普遍.
- 较低的维生素D水平与LV尺寸和减速时间受损相关,并通过STE评估显著减少全球纵向应变 (GLS).
- 维生素D补充剂 (从16.0到39.0 ng/ml) 显著改善了STE参数 (AP4L,AP3L,AP2L和GLS),表明心肌功能得到改善.
结论:
- 维生素D缺乏与 β-TM 的儿童心脏功能受损显著相关.
- 维生素D补充剂在这种患者群体中对心肌功能产生了显著的积极影响.
- 定期监测和维持足够的维生素D水平对于减轻β-TM儿童心脏不良影响至关重要.
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