系统性炎症反应指数与膀过度活跃之间的关联:一个横截面研究
Liandong Chen1, Xier Xu2, Yidong Zhou3
1The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
European journal of medical research
|June 15, 2025
概括
系统性炎症反应指数 (SIRI) 是过度活性膀 (OAB) 的重要危险因素. 较高的SIRI水平与增加的OAB症状严重程度相关,突出炎症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 炎症研究的研究.
- 公共卫生 公共卫生
背景情况:
- 过度活动的膀 (OAB) 病理生理学仍然不清楚关于炎症.
- 系统性炎症反应指数 (SIRI) 量化了系统性炎症状态.
- 这项研究调查了SIRI与OAB风险和严重程度 (OABSS) 的关联.
研究的目的:
- 评估SIRI与发展OAB的风险之间的关系.
- 为了确定SIRI和OAB症状的严重程度之间的关联.
- 探索潜在的非线性关系和子组一致性.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2005-2020年).
- 使用加权后勤和线性回归模型来分析SIRI对OAB风险和OABSS的影响.
- 应用限制立方线 (RCS) 模型进行非线性分析,并进行子组分析.
主要成果:
- 分析包括23,915个人;21% (9011) 有OAB.
- 在SIRI和OAB风险 (OR=1.268) 和严重程度 (β=0.143) 之间发现了显著的积极关联.
- RCS模型证实了非线性关系;子组分析支持跨种群的一致性.
结论:
- SIRI是膀过活的重要危险因素.
- 增加的SIRI水平与增加的OAB症状严重程度密切相关.
- 这些发现强调了系统性炎症在OAB中的作用.
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