在先前使用抗血小板药物进行内血管治疗后,结果的性别差异:来自EVA-TRISP注册表的研究
Roberta Noseda1, Federico Rea2,3, Giovanni Bianco4
1Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
European stroke journal
|June 16, 2025
概括
性别和先前的抗血小板使用不会影响机械血栓切除术 (MT) 的结果. 这项研究没有发现显著的相互作用,这表明所有接受MT的患者,无论性别或抗血小板状况如何,都应该采用统一的方法.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 医疗干预 医疗干预
背景情况:
- 机械血栓切除术 (MT) 是急性缺血性中风的关键治疗方法.
- 了解患者的性别和先前的抗血小板使用如何影响MT结果对于个性化治疗至关重要.
研究的目的:
- 评估之前使用抗血小板剂的患者机械血栓切除术 (MT) 后安全性和功能结果的性别差异.
- 要确定性别和抗血小板状况是否相互作用以影响结果.
主要方法:
- 对7472名用MT治疗的患者 (2015-2023) 的跨国注册表 (EVA-TRISP) 的分析.
- 多变量逻辑回归模型被用来分析根据性别和先前的抗血小板使用 (没有,单一或双重治疗) 的结果.
- 主要结局包括住院症状性内出血 (sICH) 和3个月修改的兰金度量 (mRS) 评分.
主要成果:
- 性别之间SICH率没有显著差异 (4.6%的女性与4.4%的男性).
- 性别和之前的抗血小板药物使用都没有显著影响sICH或更高的3个月mRS得分的几率.
- 对于sICH或mRS结局,没有观察到性别和抗血小板使用之间的显著相互作用.
结论:
- 患者的性别和先前使用的抗血小板剂之间没有明显的相互作用,这涉及机械血栓切除术的安全性和功能性结果.
- 目前的证据不支持在女性与此前服用抗血小板药物的男性中对MT采取不同的决策方法.
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