神经类固醇和月经前失调障碍
Marie Bixo1, Louise Stiernman1, Torbjörn Bäckström1
1Department of Clinical Sciences, Obstetrics and Gynaecology, Umeå University, Sweden.
概括
月经前失调障碍 (PMDD) 涉及与月经周期相关的情绪症状. 像阿洛普雷格纳诺这样的神经类药物可能会在易受影响的个体中引发PMDD,这凸显了对新的治疗点的需求.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 月经前失调障碍 (PMDD) 影响至少3%的女性,其特点是情绪症状,如抑郁,易怒和焦虑.
- 这种情况与月经周期的质阶段密切相关,神经类固醇,特别是全孕,与其病理生理学有关.
研究的目的:
- 审查当前关于正异质调节剂 (PAM) 和其他神经活性类固醇在PMDD发展中的作用的研究.
- 探索神经类固醇波动和PMDD症状之间的联系.
主要方法:
- 使用PubMed进行了一项文学搜索,其中涉及与月经前综合征,神经类固醇,全孕,GABA和雌激素相关的术语.
- 还包括了相关的动物研究和作者所知道的其他出版物.
主要成果:
- 在敏感个体中,全孕和其他GABAA受体PAM可以在高剂量时引起镇静,在较低剂量时引起焦虑/刺激.
- 研究表明,与对照人群相比,PMDD患者的脑功能和GABAA受体组成在女性中存在差异,这些差异与阿洛普雷格纳诺水平有关.
- 波动的神经活性类固醇水平似乎会加剧PMDD的症状;抑制排卵是有效的,但需要激素补充来控制副作用.
结论:
- 目前,PMDD没有确定的有效治疗方法.
- 艾洛普雷格纳诺被确定为诱发易感个体PMDD症状的关键因素.
- 未来的研究应该调查针对神经类固醇效应或GABAA受体可塑性的干预措施.
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