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生物工程工具在辅助生殖技术中的整合

Aslı Ak^1,2, Edith Coonen^2,3, Ron van Golde²

¹Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institue for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ET, The Netherlands.

Advanced healthcare materials

|June 16, 2025

概括

生物工程创新,包括微流体和干细胞,正在增强辅助生殖技术 (ART). 这些进步旨在改善生育治疗,从配体处理到胚胎植入,提供个性化疗法.

科学领域:

生殖医学生殖医学
生物工程是生物工程.
生物技术是生物技术.

背景情况:

不孕症影响全球大约17.5%的成年人,造成重大挑战.
辅助生殖技术 (ART) 对于治疗不孕症至关重要.
生物工程和生殖医学的进步为ART提供了新的解决方案.

研究的目的:

审查基于微工程和干细胞的平台,以改进ART.
综合当前关于增强异构体处理,受精,胚胎培养和植入的研究.
确定生殖疗法中的生物工程的挑战和未来方向.

主要方法:

对精子选择和处理的微流体系统的审查.
对处理卵细胞和冷保存设备的分析.
基于干细胞的胚胎模型和生物工程的子宫内膜平台的检查.

主要成果:

微流体装置在精子分类和减少伴生体应激方面表现有前途.
专门用于卵细胞处理和冷保存的设备正在出现.
干细胞模型和生物工程平台旨在模仿体内生殖环境.

结论:

微工程和干细胞技术有可能提高ART程序.
为了更广泛的应用,需要进一步开发,特别是在卵细胞处理和胚胎培养方面.
解决可扩展性,可重复性,临床验证和伦理问题对于未来的进步至关重要.

关键词:

辅助生殖技术是一种辅助生殖技术.生物工程平台的生物工程平台.这是受精,受精,受精.植入植入植入植入植入植入植入植入植入在体外模型模型中的体外模型.基于干细胞的胚胎模型

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