评估2岁儿童最佳神经发育结果的患病率,这些儿童先前接受了心室辅助设备支持
Shannon Oliver1, Jennifer Conway1, Holger Buchholz2
1Department of Pediatrics University of Alberta Edmonton AB Canada.
Journal of the American Heart Association
|June 16, 2025
概括
在接受腹腔辅助装置 (VAD) 的婴儿中,在15个月前,在25.6%的婴儿中观察到最佳的神经发育结果. 在这项VAD治疗研究中,神经损伤是唯一独立与非最佳结果相关的因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 儿科心脏手术 儿科心脏手术
- 神经发育儿科 神经发育儿科
背景情况:
- 关于接受心室辅助器械 (VAD) 治疗的儿科患者的神经发育结果的数据有限,特别是在移植后队伍之外.
- 这项研究通过检查幼年 (≤15个月) 植入VAD的婴儿的结果来弥补这一差距.
研究的目的:
- 确定使用VAD治疗的婴儿 (≤15个月) 中最佳神经发育结果的患病率.
- 在这个脆弱的患者群体中确定与非最佳神经发育结果相关的因素.
主要方法:
- 一项前性开始队列研究包括在≤15个月大时植入VAD的患者.
- 使用标准化测试 (贝利尺度,ABAS) 定义了最佳神经发育结果,并且没有特定障碍 (脑,听觉/视觉损失,发作).
- 第一次多重回归分析确定了与非最佳结果相关的独立因素.
主要成果:
- 在56名植入患者中,39名存活2年的患者进行了神经发育评估.
- 25.6%的患者获得了最佳的神经发育结果.
- 神经损伤是唯一与非最佳结果相关的独立因素 (OR,12.34;P=0.026).
结论:
- 大约四分之一的接受VAD的婴儿 (≤15个月) 在2岁时取得了最佳的神经发育结果.
- 神经性侮辱已成为与VAD接受者的非最佳神经发育结果相关的重要,潜在的可修改因素.
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