针对儿科瘤的质子束疗法后的非癌症影响 - - 一篇叙述性综述
Anna Zając-Grabiec1, Beata Biesaga1,2, Monika Krzyżowska1
1Department of Medical Physics, Cyclotron Centre Bronowice, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland.
Frontiers in oncology
|June 16, 2025
概括
质子束疗法 (PBT) 为儿科癌症患者提供精确的辐射,与传统光子疗法 (PT) 相比,可能减少诸如认知和内分泌问题的副作用. 需要进一步的研究才能充分理解脑干损伤风险.
科学领域:
- 在瘤学瘤学.
- 儿科医学 儿科医学
- 辐射瘤学 辐射瘤学
背景情况:
- 放射治疗,包括光子疗法 (PT),可导致儿童的严重并发症.
- 质子束疗法 (PBT) 提供精确的辐射输送,最大限度地减少对周围健康组织的损伤.
- 儿科患者可能会经历PBT的晚期非癌症影响,例如脑干损伤和认知,内分泌或心血管问题.
研究的目的:
- 审查和分析关于治疗质子疗法的儿科患者副作用发生的出版物.
- 从分析中排除与二次恶性瘤相关的副作用.
- 评估儿童的质子疗法后非癌症晚期影响的类型和频率.
主要方法:
- 临床试验和出版物的系统文献综述.
- 数据来源于临床试验.gov和PubMed (通过iCite).
- 分析重点关注非癌症晚期影响,不包括二次恶性瘤.
主要成果:
- 与光子疗法 (PT) 相比,质子束疗法 (PBT) 与认知,神经内分泌和心血管功能障碍的风险降低有关.
- 在PBT后,关于脑干损伤的结果是矛盾的.
- 大多数研究报告说,与PT相比,PBT后脑干损伤的累积发病率较低 (0.7%-5.0%).
结论:
- 与PT相比,PBT在儿童癌症患者中减少某些晚期毒性方面显示出潜在的益处.
- 在儿童中,PBT后脑干损伤的发生率和风险需要进一步调查.
- 前性研究对于准确地描述质子疗法在儿科患者群体中的长期影响至关重要.
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