在中等收入环境中的极度早产新生儿的生存评估
Maria J Rodriguez-Sibaja1, Olivo Herrera-Ortega1, Mario I Lumbreras-Marquez1,2
1Maternal-Fetal Medicine Division, Instituto Nacional de Perinatologia, Mexico City, Mexico.
Frontiers in pediatrics
|June 16, 2025
概括
在中等收入环境中出生的极度早产婴儿从怀孕26周开始显示出更好的生存率. 然而,生存率因计算方法而异,大多数幸存者经历了显著的新生儿发病率.
科学领域:
- 新生儿科学 新生儿科学
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,每年有1510万名早产新生儿出生,其中1%是极度早产 (孕期<28.0周).
- 极度早产婴儿的生存和结果受到妊娠年龄,出生体重和医疗资源的影响.
- 中等收入环境为新生儿护理和生存带来了独特的挑战.
研究的目的:
- 描述一个中等收入国家的极度早产婴儿的出院生存率.
- 评估与极度早产相关的新生儿发病率.
主要方法:
- 一个横截面研究分析单独怀孕.
- 新生儿存活率是用三个分母来计算的:总的极早产,所有活产,以及NICU入院.
- 新生儿发病率被评估为次要结局.
主要成果:
- 在怀孕24.6周之前出生的婴儿没有存活到出院.
- 随着妊娠年龄的增加,死亡率下降,新生儿重症监护室出院的存活率在27周达到69%.
- 根据使用的分母,生存率有很大差异.
- 97.0%的NICU幸存者被诊断出患有重大发病率.
结论:
- 在中等收入国家,极度早产婴儿的存活率超过50%,从怀孕26周开始.
- 分母的选择对所报告的新生儿存活率产生了重大影响.
- 在极度早产后的生存率与大量的新生儿发病率有关.
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