在艾滋病毒感染的中年成年人中,身体功能下降的预后因素
Grace L Kulik1, Triin Umbleja2, Todd T Brown3
1University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Open forum infectious diseases
|June 16, 2025
概括
身体功能下降的风险更高的艾滋病毒感染者包括女性,非白人,以及有抑郁病史,高BMI或炎症的人. 早期干预对于维护功能至关重要.
科学领域:
- 老年学和艾滋病病毒医学
- 临床研究和流行病学.
背景情况:
- 在PREPARE研究中,艾滋病毒感染者 (PWH) 的整体身体功能略有下降.
- 在PWH中观察到身体功能变化的显著个体变化.
- 探索性分析旨在确定最容易受到身体功能下降的PWH.
研究的目的:
- 确定与艾滋病毒感染者 (PWH) 身体功能下降相关的人口和临床因素.
- 确定在PWH人群中面临功能障碍最大风险的个体.
主要方法:
- 用线性混合效应模型计算了椅子上升,步行速度和握力的年度变化率.
- 身体功能的下降被定义为在至少一个指标上表现低于第20个百分点.
- 逻辑双项回归模型评估了基线特征和身体功能下降之间的关联.
主要成果:
- 在569名参与者中,52%的身体功能下降.
- 在女性 (RR 1.32) 和非白人 (RR 1.23) 中观察到下降的风险更高.
- 增加的风险与抑郁症治疗史,更高的BMI,虚弱和炎症标志物 (hs-CRP,IL-6) 的升高有关.
结论:
- 患有抑郁病史,高BMI,炎症或早期功能障碍的PWH有较高的风险.
- 建议采取有针对性的早期干预措施,以保护高危PWH患者的身体功能.
- 积极的策略可以缓解与艾滋病毒感染者的与年龄相关的功能衰退.
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