病例报告:抗ADAM23抗体:一种被忽视的针对自身免疫性脑炎中VGKC复合体的自身抗体
Pinfei Ni1, Lin Bai1, Nan Jiang1
1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in immunology
|June 16, 2025
概括
这项研究确定了抗ADAM23抗体作为自身免疫性脑炎 (AE) 的新病因. 这一发现扩大了VGKC复合体自身免疫的已知点,并为AE患者提供了新的诊断可能性.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 自身免疫性脑炎 (AE) 通常与向电压通道 (VGKC) 复合体的抗体有关,例如抗LGI1和抗CASPR2.
- 抗ADAM23抗体以前没有涉及AE.
相关概念视频
Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
Antigens Involved in Adaptive Immunity
1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
Autoimmune Disorders
2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K


