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慢性阻塞性肺病相关的神经认知功能障碍中的肺-大脑轴:机制性见解和潜在的治疗选择

Xiao Yu¹, Hui Xiao², Yushan Liu³

¹Department of Histology & Embryology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.

International journal of biological sciences

|June 16, 2025

概括

慢性阻塞性肺病 (COPD) 通过肺-大脑轴与大脑功能障碍有关. 氧化应激和COPD患者的炎症可能导致神经认知障碍,影响治疗的坚持和结果.

科学领域:

肺部医学肺部医学
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

慢性阻塞性肺病 (COPD) 是全球死亡的主要原因,影响超过2.10亿人.
显著的并发症,神经认知障碍影响60%的COPD患者,恶化结果和增加死亡率.
慢性肺炎患者的认知功能受损导致治疗坚持不良和住院率较高.

研究的目的:

探索COPD肺脑轴及其对神经认知障碍的贡献.
讨论下丘脑-垂体-上腺 (HPA) 轴在COPD进展和认知衰退中的作用.
审查潜在的抗炎和抗氧化疗法,以治疗COPD和相关的认知缺陷.

主要方法:

对COPD肺脑轴现有文献的综述.
系统性炎症和氧化应激对血脑屏障 (BBB) 透性的影响的分析.
在COPD病变发生过程中检查下丘脑-垂体-上腺 (HPA) 轴.
编制针对COPD和认知功能障碍的治疗策略.

主要成果:

肺氧化应激和COPD中的炎症可能会破坏血脑屏障 (BBB),导致大脑功能障碍.
垂体-垂体-上腺 (HPA) 轴在COPD进展和神经认知缺陷的发展中发挥着作用.
神经元缺陷和改变的质细胞功能有助于COPD患者的认知障碍.
抗炎和抗氧化疗法在治疗COPD和相关认知问题方面表现有前途.

结论:

肺-大脑轴提供了COPD和神经认知障碍之间的机械联系.
针对炎症和氧化应激可能对治疗COPD患者的认知功能障碍至关重要.
对HPA轴和新型治疗干预措施的进一步研究是全面COPD护理的必要条件.

关键词:

与COPD有关的神经认知障碍 (COPD-NCDs)慢性阻塞性肺病 (COPD) 是一种慢性阻塞性肺病.炎症炎症是一种炎症.肺 - 脑轴 - 肺 - 脑轴神经认知障碍神经认知障碍氧化压力.氧化压力.

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