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Updated: Sep 19, 2025

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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与KBG综合征相关的蛋白质ANKRD11调节SETD5的表达,以调节rRNA水平和翻译

Shoko Sashiyama1,2, Tadashi Nakagawa1,3, Makiko Nakagawa3,4,5

  • 1Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Sanyo-Onoda 756-0884, Japan.

iScience
|June 16, 2025
PubMed
概括

缺少ANKRD11会损害神经细胞中的核糖体RNA (rRNA) 生产和翻译,导致KBG综合征. 通过ANKRD11-SETD5轴调节SETD5,可以恢复rRNA水平,并可能提供治疗效益.

关键词:
细胞生物学 细胞生物学分子生物学分子生物学

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