皮层刺激和抑制神经元激活的时空属性通过持续和爆发的电微刺激来激活神经元
Christopher L Hughes1,2, Kevin C Stieger1,2, Keying Chen1,2
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
iScience
|June 16, 2025
概括
皮层内微刺激 (ICMS) 不同地影响大脑细胞. 抑制性神经元增加活动,而激发性神经元减少,揭示了对长时间刺激的独特神经反应.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 感官系统 感官系统
背景情况:
- 皮层内微刺激 (ICMS) 可以唤起人造感觉.
- 在ICMS期间的感知色表明了动态的神经变化.
- 了解这些变化对于大脑与计算机接口至关重要.
研究的目的:
- 研究长期ICMS对视觉皮层激发性和抑制性神经元的差异性影响.
- 探索不同的刺激模式如何调节神经元活动.
- 阐明抑制和消抑制在塑造皮质对ICMS反应中的作用.
主要方法:
- 在转基因小鼠中进行双光子成像.
- 长时间的ICMS (30秒) 应用.
- 激发性和抑制性人群中神经元活动的分析.
主要成果:
- 在ICMS期间,抑制性神经元活动通常会增加,而激发性神经元活动会减少,并显示出刺激后的抑制.
- 甲爆刺激优先激活抑制性神经元.
- 10Hz爆发刺激优先激活刺激神经元.
- 离电极更远的神经元表现出更多样化的反应,表明复杂的突触相互作用.
结论:
- 在长时间的刺激过程中,ICMS对刺激神经元和抑制神经元产生不同的影响.
- 刺激模式调制可以选择性地参与特定的神经元类型.
- 研究结果表明,通过优化ICMS参数,有可能塑造皮质活动.
更多相关视频
10:45Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
Published on: May 29, 2017
10.0K
07:52Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
371
相关概念视频
Action Potentials
112.8K
Overview
112.8K
Long-term Potentiation
51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Action Potential
10.2K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
10.2K
Neurochemical Transmission: Sites of Drug Action
3.5K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.5K
Action Potential
9.6K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
9.6K
Action Potential: Phases of Stimulation
20.6K
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
20.6K
