电梯按上的微生物群落结构和抗体动态,是对表面消毒实践的反应
Shanshan Ye1,2, Shifu Peng1, Xiaolei Wang1,3
1Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Frontiers in public health
|June 16, 2025
概括
在酒店和医院等公共场所经常使用消毒剂可能会增加细菌耐药性. 这项研究在隔离酒店的表面上发现了更高的消毒剂和抗生素耐药性基因,这表明消毒实践可以选择耐药细菌.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 公共卫生 公共卫生
背景情况:
- 在COVID-19大流行期间广泛使用消毒剂,旨在控制病毒传播.
- 有关消毒剂对细菌社区结构和耐药性的影响存在担忧.
- 公共空间的电梯按是高触摸表面,有可能传播微生物.
研究的目的:
- 调查消毒剂使用对细菌社区结构的影响.
- 确定消毒剂的使用是否有助于细菌对消毒剂和抗生素的耐药性.
- 在电梯按上分析消毒剂耐药性基因 (DRG),抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE) 的流行情况.
主要方法:
- 在电梯按表面使用元基因组测序和定量PCR (qPCR) 分析细菌群落.
- 在三级医院,传染病医院,隔离酒店和普通酒店进行采样.
- 在环境样本中检测DRG,ARG和MGE.
主要成果:
- 在四个环境中观察到细菌社区结构的显著差异.
- 隔离酒店,频繁消毒,显示出明显的细菌形状和较低的多样性 (α和β).
- 在隔离酒店中发现了DRG,ARG和MGE以及抗生素耐药细菌 (例如大肠杆菌,A. baumannii) 的高丰度.
结论:
- 电梯按上的细菌社区结构受消毒剂使用频率的影响.
- 交通繁忙的地区的消毒做法可能会促进耐药细菌的选择和传播.
- 加强监测和完善的消毒协议在医院和酒店中至关重要,以减轻耐药性的传播.
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