在坦桑尼亚达累斯萨拉姆首次治疗肺结核的患者中,肺功能异常的变化
Reinhard Elisania Lema1,2, Grace Ambrose Shayo1, Zuhura Nkrumbih1
1Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, Tanzania.
概括
近一半完成结核治疗的患者表现出异常的肺功能. 男性的性别,体重不足,以及起始时的肺腔膜或纤维化与较差的结果有关,需要有针对性的注意.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肺结核 (PTB) 是一个重要的全球健康问题.
- 治疗后评估肺功能 (PF) 对于了解长期后果至关重要.
- 首次出现的PTB病例需要对残留肺损伤进行具体评估.
研究的目的:
- 记录患者在第一次PTB治疗完成后的肺功能异常.
- 为了确定与治疗结束时异常肺功能相关的因素.
- 为PTB幸存者提供临床管理和后续策略的信息.
主要方法:
- 这是一项前性研究,涉及332名年龄≥15岁的患者,他们正在接受已确认PTB的治疗.
- 肺功能测试在基线和治疗结束时进行.
- 统计分析包括威尔科克森签名等级测试的变化和相关因素的日志二项式回归.
主要成果:
- 在治疗结束时,47.3%的患者 (142/300) 观察到异常的肺功能.
- 与异常PF显著相关的因素包括男性性别,体重不足状况和基线肺腔化或纤维化.
- 平均FEV1和FVC从基线到治疗结束时显著改善,但在许多人中仍然不理想.
结论:
- 大约一半的患者在PTB治疗后出现肺功能异常.
- 体重不足的患者,男性,以及基线肺腔化或纤维化患者,患有持续性PF异常的风险更高.
- 这些发现凸显了针对性干预和对处于风险中的PTB幸存者的更密切监测的需要.
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