关于在多个体位结直肠癌数据集中探索微生物组的横截面稳定性和持久性
Hajra Ashraf1,2, Sama Rezasoltani3, Mohammad Mehdi Feizabadi4
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Frontiers in microbiology
|June 16, 2025
概括
研究人员确定了包括Actinobacteriota和Fusobacterium在内的关键肠道细菌,作为结直肠癌 (CRC) 的潜在生物标志物. 一些微生物在唾液和便中表现出类似的模式,支持CRC诊断的口腔肠轴连接.
科学领域:
- 微生物组研究的研究.
- 癌症诊断 癌症诊断 癌症诊断
- 肠-大脑轴 肠-大脑轴
背景情况:
- 与疾病相关的微生物群签名可以通过核心物种或稳定的子社区来识别.
- 不同的微生物模式可能在不同的身体部位一致.
- 分析策略的进步使复杂的微生物组数据能够更深入地探索.
研究的目的:
- 在一个多因素的伊朗结肠直肠癌 (CRC) 数据集中调查稳定和持久的微生物组模式.
- 为了确定CRC的潜在微生物诊断生物标志物.
- 探索 CRC 患者口腔和肠道微生物组之间的关系.
主要方法:
- 从CRC患者的唾液和便样本和健康对照组 (n=80) 中分析16SrRNA基因序列.
- 整合通过问卷收集的人口和营养数据.
- 探索微生物物种的流行率和体位的差异性模式.
主要成果:
- 在CRC患者中,特定微生物物种 (Actinobacteriota,Bifidobacterium,Prevotella,Fusobacterium) 的持续存在表明潜在的诊断生物标志物.
- 在唾液和便中识别具有类似差异反应的微生物 (Akkermansia,Selenomonas,Clostridia_UCG-014,Lautropia,Granulicatella,Bifidobacterium,Gemella).
- 证据支持使用唾液微生物组作为便微生物组的代理,加强CRC的口腔肠轴.
结论:
- 稳定的微生物生物标志物可以通过最小化变异性在多因素CRC数据集中识别.
- 特定的细菌显示希望作为结直肠癌的诊断标记.
- 口腔微生物组可以作为CRC肠道微生物组变化的非侵入性指标,突出口腔-肠轴.
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