在原始的荷尔斯坦牛中,与自发流产相关的位点
Emaly M Suarez1, Victoria C Kelson1, Jennifer N Kiser1,2
1Department of Animal Sciences, Washington State University, Pullman, WA, United States.
Frontiers in veterinary science
|June 16, 2025
概括
在牛群中,自发流产 (SA) 造成了重大经济损失. 这项研究确定了Holstein奶牛中与SA相关的遗传位点,通过选择来提高生殖效率的潜力.
科学领域:
- 遗传学 是一个遗传学.
- 动物科学动物科学
- 生殖生物学 生殖生物学
背景情况:
- 牛的自发性流产 (SA),定义为42至260天之间的妊娠流产,造成了相当大的经济损失并影响了牛群的生产力.
- 这种疾病会导致宝贵的养殖奶牛过早被杀,需要基因洞察来缓解.
研究的目的:
- 为了确定与原生荷尔斯坦牛的自发流产相关的特定遗传位置.
- 通过人工授精 (AI) 繁殖的牛与接受胚胎移植 (ET) 的牛中对SA的遗传关联进行区分.
主要方法:
- 进行了全基因组关联分析,对荷尔斯坦牛进行了分析.
- 分析了两个不同的队列:人工智能繁殖的奶牛 (679个对照,69个病例) 和接受ET的奶牛 (236个对照,41个病例).
主要成果:
- 在人工智能养的奶牛中,86个位点和168个候选基因与SA显著相关 (FDR <0.05).
- 在ET接受者中,4个位点和16个候选基因与SA相关 (FDR <0.05).
- 人工智能繁殖和ET接受者群体之间没有与SA相关的基位共享,尽管人工智能繁殖的奶牛和公牛之间共享了9个基位.
结论:
- 与SA相关的遗传位点在通过AI和ET受孕的牛之间存在差异,可能是由于妊娠维持机制的变化.
- 识别这些位点为基因选择提供了基础,以提高Holstein牛的生殖效率并减少SA.
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