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遵守地中海饮食和发生急性胰腺炎:一项前性队列研究
Chunhua Zhou1, Jiawei Geng2, Zhipeng Wu1
1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Therapeutic advances in gastroenterology
|June 16, 2025
概括
更严格地遵守地中海饮食 (MedDiet) 显著降低了急性胰腺炎 (AP) 的风险. 这种饮食模式也有助于减轻AP的遗传倾向,部分是通过减少炎症和改善代谢状态.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 预防医学 预防医学
背景情况:
- 地中海饮食 (MedDiet) 坚持与急性胰腺炎 (AP) 风险之间的关联在很大程度上仍未被描述.
- 了解这种关系对于开发针对AP的预防策略至关重要.
研究的目的:
- 调查MedDiet坚持和AP风险之间的关联.
- 检查遗传风险和MedDiet遵守对AP风险的综合影响.
主要方法:
- 使用英国生物库数据的前性队列研究 (n=103,449).
- 使用地中海饮食坚持选器 (MEDAS) 评估的MedDiet坚持.
- 通过多基因风险评分 (PRS) 估计的遗传风险;通过电子医疗记录识别的AP病例.
主要成果:
- 较高的MedDiet坚持与较低的AP风险相反相关 (HR 0.60;95% CI 0.46-0.79).
- 炎症和代谢状态部分介导了这种关联 (分别为10%和7.1%).
- 结合低遗传风险和高的MedDiet坚持,AP风险最低 (HR0.54;95%CI0.36-0.80).
结论:
- 增加MedDiet的坚持与AP的风险降低有关.
- 保护作用的部分介于减少炎症和改善代谢健康.
- 坚持MedDiet可能会抵消对AP的遗传敏感性.
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