在长期使用阿片类药物治疗的退伍军人中,物质使用和使用障碍
Thye Peng Ngo1,2, Salomeh Keyhani1,3, Samuel Leonard1
1Center for Data to Discovery and Delivery Innovation (3DI), San Francisco VA Health Care System, CA, USA.
Drug and alcohol dependence reports
|June 16, 2025
概括
药物使用障碍 (SUD) 在长期服用阿片类药物治疗 (LTOT) 的退伍军人中很常见,并显著增加死亡率和过量使用风险. 针对性干预和综合查对这一群体至关重要.
科学领域:
- 公共卫生 公共卫生
- 临床研究 临床研究
- 退伍军人健康 退伍军人的健康
背景情况:
- 有限的研究存在于药物使用和药物使用障碍 (SU/SUD) 的流行率和经过长期阿片类药物治疗 (LTOT) 的退伍军人中相关的健康风险.
- 健康记录数据为估计SU/SUD流行率及其对LTOT退伍军人死亡率的影响提供了宝贵的资源.
研究的目的:
- 估计在LTOT的退伍军人中SU/SUD的流行率.
- 确定SU/SUD与死亡率之间的关联,包括所有原因死亡率,致命过量服用和创伤性死亡,在LTOT的退伍军人中.
主要方法:
- 在2014年至2019年期间,对来自退伍军人卫生管理局门诊机构的队列数据进行了二次分析.
- 通过对风险酒精使用的积极查,尿液中大麻,二或兴奋剂的药物测试,或经过记录的SUD诊断来确定SU/SUD.
- 考克斯模型被用来比较退伍军人在LTOT与SU/SUD之间以及那些只接受LTOT的退伍军人之间的死亡率.
主要成果:
- 大约25.0%的退伍军人在LTOT上表现出危险的酒精使用,对其他物质的检测呈阳性,或被诊断为SUD.
- 酒精是最常见的SU/SUD (9.8%),其次是镇静剂 (8.1%),大麻 (6.6%) 和兴奋剂 (0.6%).
- 与大麻,镇静剂或兴奋剂SU/SUD一起服用LTOT的退伍军人显示死亡率更高. 对于那些使用酒精,镇静剂或兴奋剂的人来说,致命的过量剂量率是高的 SU/SUD. 镇静剂SU/SUD也与创伤性死亡率的增加有关.
结论:
- 在LTOT的退伍军人中,共同使用物质很普遍.
- 在这个人群中,SU/SUD与显著增加的死亡率和致命过量剂量的风险有关.
- 建议进行全面的查和有针对性的干预措施以减轻这些风险.
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