在睡眠剥夺期间高能量酸盐消耗的半球不对称性被肌酸平衡
Ali Gordji-Nejad1, Andreas Matusch1, Sophie Kleedörfer2
1Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, Jülich, Germany.
Frontiers in neuroscience
|June 16, 2025
概括
睡眠不足会通过影响大脑半球的能量使用来损害认知. 肌酸补充剂有助于平衡这种不对称性,特别是在左半球,通过改变能量酸盐水平.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 认知科学 认知科学
背景情况:
- 人类大脑表现出横向活动模式,特别是在睡眠和清醒期间.
- 众所周知,睡眠不足会导致认知缺陷,可能与半球失衡有关.
- 高能酸盐 (HEP) 对大脑功能至关重要,但它们在睡眠剥夺期间的半球消耗不足.
研究的目的:
- 为了研究睡眠剥夺期间高能量酸盐 (HEP) 消耗的半球差异.
- 分析肌酸补充剂对睡眠剥夺引起的大脑代谢不对称性的影响.
主要方法:
- 重新分析之前收集的关于接受21小时睡眠剥夺和认知测试的受试者的数据.
- 对腺三酸盐 (ATP),脂蛋白/无机酸盐 (PCr/Pi) 和其它代谢产物进行了voxel-wise的半球间比较.
- 在单独的会议中评估肌酸单酸对代谢不对称的影响.
主要成果:
- 与睡眠剥夺后的左半球相比,右半球观察到ATP的较大减少.
- 部分体积校正表明灰色物质与白色物质中的PCr/Pi下降率更高.
- 肌酸补充剂显著降低了睡眠剥夺引起的半球不对称性,主要是通过增加PCr/Pi和减少左半球的ATP.
结论:
- 这些发现支持了夜间活跃的右半球概念,其证据是ATP水平降低.
- 肌酸的管理有效地抵消睡眠剥夺引起的半球代谢不对称.
- 这表明肌酸在减轻与睡眠剥夺相关的认知障碍方面可能具有治疗作用.
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