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在NHANES 1999-2018中,甘油三-葡萄糖指数预测了中风后全因死亡率

Jiaqian Zheng^1,2,3, Weiwen Mao², Mengqian Sang³

¹Department of Respiratory Medicine, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou, China.

Frontiers in aging neuroscience

|June 16, 2025

概括

三甘-葡萄糖-体重指数 (TyG-BMI) 可能会降低中风后死亡风险,而三甘-葡萄糖-腰高度比 (TyG-WHtR) 可能会增加它. 控制肥胖可能是中风幸存者的关键.

科学领域:

心脏病学心脏病学
神经学神经学
代谢综合征是代谢综合征的一种.

背景情况:

卒中幸存者面临着显著的死亡风险.
基于甘油三醇和葡萄糖的指数正在成为代谢健康的潜在生物标志物.
这些指数在中风后生存期的预后价值仍未完全阐明.

研究的目的:

调查基于甘油三糖的指数,特别是TyG-BMI和TyG-WHtR在预测中风患者死亡率方面的预后相关性.
探索TyG-BMI和TyG-WHtR与中风队列中全因死亡风险之间的关联.

主要方法:

分析了796名中风患者的队列.
使用多变量Cox比例风险回归模型与采样权重.
限制立方线函数评估非线性关联和相互作用术语用于分层分析.

主要成果:

较高的TyG-BMI四分位数与死亡风险显著降低有关 (HR 0.20,95% CI:0.08-0.50).
TyG-WHtR的最高四分位数与所有原因的死亡率有很强的正相关性 (HR 4.61,95% CI: 1.77-12.00).
在TyG-BMI和死亡率之间发现了显著的非线性关联 (p < 0.05).

结论:

降低的TyG-BMI和升高的TyG-WHtR与中风患者的死亡风险增加有关.
这些指数可以作为中风后生存的有价值的预后工具.
准肥胖症可能是缓解这一群体死亡率的关键策略.

关键词:

尼汉斯 (NHANES) 是一个名人.与 TyG 相关的指数.死亡率死亡率后期的队列分析是回顾性的队列分析.一次性中风中风中风中风中风

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