在早产期晚期低出生体重新生儿中,脂质代谢失调:对母体脂质水平和早期代谢编程影响的病例对照研究
Jing Liu1,2, Lijuan Tang1,3, Qi Sun1
1Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China.
PeerJ
|June 16, 2025
概括
晚期早产期低出生体重 (LPTB-LBW) 的新生儿表现出明显的脂质变化,包括高血糖脂和胺. 孕产妇的高密度胆固醇水平与这些新生儿脂质变化相关,这表明早期代谢编程的影响.
科学领域:
- 新生儿新陈代谢 新生儿新陈代谢
- 利皮多米克 (Lipidomics) 是一种消化剂.
- 围产期编程是指围产期的编程.
背景情况:
- 低出生体重 (LBW) 是已知的成人代谢综合征的危险因素.
- 晚期早产低出生体重 (LPTB-LBW) 新生儿的特定脂质代谢特征尚不清楚.
- LPTB-LBW婴儿面临着妊娠缩短和子宫内生长限制的双重挑战.
研究的目的:
- 为了研究LPTB-LBW新生儿的独特脂质学表型.
- 为了确定早产和生长限制是否协同破坏新生儿的脂质代谢编程.
- 探索母体脂质水平与新生儿脂质概况之间的关系.
主要方法:
- 超高性能液体色谱-并联质谱 (UPLC-MS/MS) 用于分析血脂质谱.
- 研究了88名新生儿:45名LPTB-LBW和43名晚期早产-正常出生体重 (LPTB-NBW) 控制.
- 多变量和单变量统计分析确定了歧视性脂质,并评估了母婴脂质连续性.
主要成果:
- 在1,173个确定的脂质中,349个在LPTB-LBW新生儿中显著不同.
- 在LPTB-LBW婴儿中,甘油脂 (特别是甘油三) 和陶酸的调节显著上升.
- 孕产妇高密度脂蛋白胆固醇 (HDLC) 与特定的新生儿脂质 (如三糖醇和胺) 有负相关性.
结论:
- LPTB-LBW新生儿表现出一种独特的脂质体现型,其特点是过度积累的甘油脂和升高的胺.
- 母亲的HDLC水平与特定的新生儿脂质样本有关.
- 在LPTB-LBW婴儿中,这些早期的脂质变化需要进一步调查临床影响.
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