在患有甲状腺眼病的患者中,视神经头部的血流变化使用光学连贯断层扫描血管造影
Shenglan Cao1, Rongfeng Liao1, Chengbo Fang1
1Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in medicine
|June 16, 2025
概括
甲状腺眼病 (TED) 患者的视神经头部血流减少,可通过光学连贯断层扫描血管学 (OCTA) 检测到. OCTA在TED中发现了微血管变化,与视觉敏度和眼内压力相关.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 甲状腺眼病 (TED) 可以影响视神经头部 (ONH).
- 在ONH中的微血管变化可能会导致TED中的视觉功能障碍.
- 光学连贯断层扫描血管造影 (OCTA) 是一种非侵入性成像技术,用于评估ONH血管.
研究的目的:
- 用OCTA对TED患者的ONH血流变化进行评估.
- 为了比较TED患者和健康对照者 (HCs) 之间的周周血管密度 (VD) 和视网膜神经纤维层厚度 (RNFLT).
- 在TED中探索ONH血管变化和临床参数之间的相关性.
主要方法:
- 总共包括59个TED患者的59只眼睛和39个HC的39只眼睛.
- 用OCTA测量周囊性静脉疾病和RNFLT,用一个以ONH为中心的4.5*4.5mm扫描仪测量.
- TED患者被分为活跃和不活跃的组;进行了相关性分析.
主要成果:
- 与HC相比,不活跃的TED患者在上鼻 (SN) 和上 (ST) 部门的辐射周囊毛细血管VD显着较低 (p <0.05).
- 两组之间没有发现周周毛囊RNFLT的显著差异.
- 视力敏度下降与特定的周周毛囊视力损伤和RNFLT测量正相关,眼内压与RNFLT相关.
结论:
- 在TED患者中,OCTA有效检测微血管ONH变化.
- 在不活跃的TED中存在减少的外皮皮质静脉疾病,这表明血管妥协.
- 在TED患者中,OCTA的发现可能与视觉功能和眼内压力有关.
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