甲-呼吸试验与肠道菌群检测相结合的诊断价值,用于查结直肠多
Wei Wang1,2, Hui Li1,2, Zhihui Yan1,2
1Chinese PLA Medical School, Beijing, China.
甲和气呼吸测试 (MHBT),结合肠道菌群分析,显示了对非侵入性结肠直肠多检查的前景. 这种综合方法显著提高了诊断准确性,而不是单独使用呼吸测试.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 诊断医学 诊断医学 诊断医学
背景情况:
- 结肠直肠多是结肠直肠癌的前体,需要有效的查方法.
- 目前的查方法在可访问性和侵入性方面存在局限性.
- 甲和呼吸测试 (MHBT) 和肠道菌群分析是新兴的生物标志物.
研究的目的:
- 评估将甲和呼吸测试 (MHBT) 与肠道菌群检测结合用于结直肠多检查的诊断价值.
- 评估这种综合方法在区分患有或没有结直肠息肉的患者中的有效性.
主要方法:
- 一项回顾性研究包括196名接受结肠镜检查和MHBT的患者.
- 患者被分为对照组 (没有息肉) 和观察组 (息肉).
- 分析包括肠道屏障功能标记物,瘤标记物,MHBT结果和肠道菌群的相对丰富性,并对诊断疗效进行ROC曲线分析.
主要成果:
- 在多组中,MHBT对CH4和H2的阳性显著更高.
- 特定的肠道细菌,包括Bifidobacterium spp., Lactobacillus spp. 和Clostridium nucleatum,在患有多重体的患者中显示出改变的丰度.
- 综合试验 (MHBT + 植物) 的AUC为0.831,具有79.27%的灵敏度和82.90%的特异性来诊断结直肠多.
结论:
- 甲和呼吸试验 (MHBT) 与肠道菌群分析相结合,为结直肠多检查提供了一个非侵入性策略.
- 整合植物标记物显著提高了诊断效率,表明了优化查途径的翻译潜力.
- 建议进一步研究植物 - 代谢气体相互作用的机制和个性化值.
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