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Updated: Jul 20, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
16:16

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

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使用AlphaFold3用于GPCR调制和癌症治疗的CXCR4向抗体的皮导向选择

Srimathi Venkataraman1, Yi-Chuan Li2, Zi-Wei Hung3

  • 1Graduate Institute of Biological Science and Technology, China Medical University Taichung 406040, Taiwan.

American journal of cancer research
|June 16, 2025
PubMed
概括

研究人员使用AlphaFold3.3确定了G蛋白结合受体 (GPCR) 上的关键相互作用部位. 这导致了抗体的发展,这些抗体阻断了信号传递,并向表达CXC化学因子受体4 (CXCR4) 的癌细胞.

关键词:
阿尔法Fold3是什么意思在CXCL12中,CXCL12是最重要的.在CXCR4中,CXCR4是最常见的.在GPCR中,GPCR是指GPCR.抗体是一种抗体.菌体显示器可以显示菌体.

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