尼格里克人阿坎索斯作为代谢功能障碍相关的性肝病的临床风险标志物
Adriana Sánchez-García1, María Eugenia Penados-Ovalle1, René Rodríguez-Gutiérrez1,2,3
1Endocrinology Division, Facultad de Medicina y Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico.
Clinical medicine insights. Endocrinology and diabetes
|June 16, 2025
概括
尼格里卡斯阿坎托斯 (AN) 可以预测肥胖成年人肝硬化症的更高程度. 这一发现支持AN作为一种有价值,低成本的查工具,用于在资源有限的环境中检测代谢功能障碍相关的脂肪性肝病 (MASLD).
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
- 皮肤病学 皮肤病学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 与胰岛素抵抗有关.
- 尼格里卡斯白血病 (AN) 是一种与胰岛素耐药性相关的临床症状.
- 关于AN在预测MASLD中的实用性存在有限的研究.
研究的目的:
- 调查尼日利亚白病 (AN) 作为MASLD的风险因素的作用.
- 评估AN作为MASLD临床预测剂的有效性.
主要方法:
- 横截面研究设计,包括临床病史和体检.
- 评估AN在特定解剖部位的存在.
- 使用过渡性弹性扫描 (FibroScan) 来评估肝脂肪 (CAP) 和肝硬度 (kPA).
主要成果:
- 在251名参与者中,63.7%的参与者有AN;65.7%的参与者有肝硬化症.
- 甲是肝脏肥胖症的重要危险因素 (调整后OR为1.97).
- 存在AN,特别是在手指节上,预测了较高的脂肪酸水平 (S2,S3).
结论:
- 尼格里卡斯阿坎索斯 (Acanthosis nigricans) 有效地预测了超重/肥胖成年人肝硬化症的高度.
- 在资源有限的环境中,AN作为MASLD的实际选工具.
- 需要进一步的研究,以便在不同人群中早期识别代谢风险因素.
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