调查遗憾和注意力缺陷/多动性障碍的多基因风险之间的基因环境相互作用在青少年时期对外部化行为进行了调查
Ana Lucia Espinosa Dice1,2, Henri M Garrison-Desany1,2, Andrew Ratanatharathorn1,2,3
1Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAACAP open
|June 16, 2025
概括
在青春期失去一个亲密的朋友会增加外部化症状,如过度活跃和行为问题. 在这项研究中,注意力缺陷/多动障碍 (ADHD) 的遗传风险并没有使这些后损失症状恶化.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 青少年的丧显著影响心理健康,但外化行为仍未得到充分研究.
- 在失去朋友后,精神病理学的遗传基础尚未得到充分理解.
- 现有的研究主要侧重于内化障碍,忽视了悲伤青少年的外化行为.
研究的目的:
- 研究注意力缺陷/多动症 (ADHD) 的多基因风险与失去亲密朋友之间的相互作用.
- 检查朋友丧失对青少年外表症状的影响,包括过度活跃/不注意和行为问题.
- 了解遗传责任在悲伤后塑造精神病理学的作用.
主要方法:
- 利用了来自Avon长度研究父母和孩子中的3,922名青少年的数据.
- 评估了自己报告的12岁至16岁之间亲密朋友的丧失.
- 采用多基因风险评分 (PRS) 对ADHD和零膨胀负二项式 (ZINB) 模型来分析16岁时的结果.
主要成果:
- 近10%的青少年报告说失去一个亲密的朋友.
- 在调整了损失前的精神病理后,丧失独立地预测了多动/不注意症状的增加 (IRR=1.18) 和行为问题 (IRR=1.40).
- 多基因ADHD风险评分没有显著预测后损失外化症状.
结论:
- 青少年丧生对心理健康产生负面影响,增加了需要临床关注的外部化症状.
- 丧亲可能会加剧现有的外部化症状,而不是仅仅创造新的症状.
- 对ADHD的遗传责任可能不会显著增加丧失后精神病理的风险,尽管需要进行更大的研究.
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