产后抑郁症增加了后代自闭症诊断的风险
Morgan R Peltier1,2, Michael J Fassett3,4, Nana A Mensah5
1Hackensack Meridian School of Medicine, Nutley, New Jersey.
母亲产后抑郁症 (PPD) 与儿童患自闭症谱系障碍 (ASD) 诊断的风险更高有关. 这种关联在不同的妊娠年龄,性别和种族/民族群体中保持一致.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发育儿科 发育儿科
背景情况:
- 母亲的精神病理是神经发育障碍的已知危险因素.
- 在后代中产后抑郁症 (PPD) 和自闭症谱系障碍 (ASD) 之间的特定关联需要进一步澄清.
研究的目的:
- 为了调查母亲的PPD诊断增加了后代ASD诊断的风险的假设.
- 要确定这种关联是否独立于妊娠年龄,孩子的性别或种族/种族.
主要方法:
- 使用297,720对母婴对的电子健康记录 (EHR) 进行的回顾性队列研究.
- 在EHR中使用ICD代码识别PPD和ASD诊断.
- 边际考克斯比例危险模型,以评估母体PPD和后代ASD之间的关联.
主要成果:
- 患有PPD的母亲的孩子患有ASD诊断的发病率较高 (9.11/1000人年),与没有PPD (5.48/1000人年) 的孩子相比.
- 母亲的PPD诊断与后代的ASD风险增加有关 (HR=1.57,95%CI=1.49-1.65).
- 在早产和满产婴儿,男性和女性中观察到这种关联,没有显著的种族/民族异质性.
结论:
- 母亲产后抑郁症与儿童患自闭症谱系障碍诊断的风险增加有显著关联.
- 这种关联是独立于关键的人口和围产因素,包括妊娠年龄,儿童性别和种族/种族.
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