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机械辅助的肝脏非侵入性通风SABR:改善CBCT,更准确地治疗

Julien Pierrard^1,2, Nicolas Audag^3,4, Christel Abdel Massih²

¹Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Université Catholique de Louvain, Brussels, Belgium.

Clinical and translational radiation oncology

|June 16, 2025

概括

机械辅助的非侵入性通风诱导的呼吸暂停 (MANIV-BH) 显著改善了形光束计算机断层扫描 (CBCT) 的图像质量和肝脏立体性废除性放射治疗 (SABR) 的图像引导放射治疗 (IGRT) 的准确性. 这种技术增强了自我细分,并减少了治疗的变化.

科学领域:

医学物理医学物理
放射治疗技术放射治疗技术
瘤成像学成像学

背景情况:

呼吸机运动人工物降低了形光束计算机断层扫描 (CBCT) 图像质量在肝脏的刻板式除性放射治疗 (SABR).
这些文物可能会损害图像引导放射治疗 (IGRT) 的准确性.
机械辅助非侵入性通风诱导的喘息 (MANIV-BH) 是一种减轻呼吸运动的技术.

研究的目的:

为了比较MANIV-BH与自由呼吸 (FB) CBCT在肝脏中的有效性,SABR.
为了评估对图像质量,IGRT可变性,自动注册准确性和深度学习自动细分性能的影响.

主要方法:

进行了对25个FB和25个MANIV-BH肝 SABR CBCT数据集的盲目比较.
14名运营商评价了图像质量和IGRT易用性.
评估了运营商间IGRT变异性,自动GTV映射精度和OAR自动细分性能.

主要成果:

MANIV-BH显著提高了CBCT图像质量 (83.4%与25.4%的优秀/好) 和IGRT易度 (68.0%与38.9%的非常容易/容易).
MANIV-BH降低了IGRT变异性 (3.2毫米对4.6毫米),并显著增强了深度学习的OAR自动细分 (80.0%对4.0%优秀/好),减少了54.2%的手动校正时间.
自动GTV映射精度在MANIV-BH和FB之间没有显著差异.

结论:

MANIV-BH显著改善了CBCT质量,降低了IGRT的变异性,并增强了肝脏SABR中的OAR自分化.
MANIV-BH对于减轻呼吸运动是安全有效的,在治疗过程中提高了治疗的准确性.
实施MANIV-BH需要专门的资源,但为肝脏SABR.提供了巨大的好处.

关键词:

在CBCT质量方面.图像指导放射治疗是指导图像的放射治疗.肝脏的SABR是一种SABR.机械辅助的非侵入性通风系统呼吸运动管理呼吸运动管理

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