肠道微生物群的变化伴随着肠道透率的增加和Tfh/Tfr失衡在患有SLE活性的患者
Xiaodi Chu1, Shuya Li2, Yueying Wang3
1Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong, China.
Frontiers in cellular and infection microbiology
|June 16, 2025
概括
系统性红斑狼 (SLE) 患者表现出肠道透性增加和肠道微生物组变化. 这些变化与免疫细胞失衡相关,可能为SLE提供新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 系统性红斑狼 (SLE) 与免疫失调有关.
- 肠道透性和肠道微生物群的改变可能会影响SLE的发病.
- 在SLE中肠道菌群,免疫细胞和细胞因子之间的相互作用需要进一步研究.
研究的目的:
- 研究SLE患者的肠道微生物群组成和免疫细胞群 (Tfh,Tfr,Treg) 之间的关系.
- 探索肠道透性,肠道微生物组和SLE中的细胞因子概况之间的联系.
- 确定这些因素与SLE疾病活动的相关性.
主要方法:
- 用流细胞计量测量Tfh,Tfr和Treg细胞在23个活跃的SLE,18个稳定的SLE和24个健康对照中.
- 16S rRNA基因测序分析了便样本以描述肠道微生物组合.
- 评估了肠道微生物群,佐努林水平 (肠道透性),SLE疾病活性指数 (SLEDAI-2k) 和细胞因子水平 (IL-2,IL-6,IL-21) 之间的相关性.
主要成果:
- 活跃的SLE患者表现出Treg细胞减少,Tfh/Tfr比率不平衡,和zonulin水平增加,表明肠道屏障功能受损.
- 较高的佐努林水平与埃舍里希亚-西格拉菌的占主导地位和显著的Tfh/Tfr不平衡有关.
- 降低IL-2水平与减少的鲁米诺菌相关,可能有助于减少SLE进展的Treg细胞.
结论:
- 增加肠道透性,以佐努林为指标,可能导致SLE的Tfh/Tfr免疫失衡.
- 肠道细菌如Faecalibacterium和Ruminococcus可能通过调节Treg细胞和Tfh/Tfr平衡来影响SLE.
- 这些发现表明了SLE潜在的基于细胞因子的治疗策略.
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