对SARS-CoV-2尖端蛋白的SUMOylation是广泛抗病毒疗法的关键目标

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Updated: Sep 19, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
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Engineering Antiviral Agents via Surface Plasmon Resonance

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Xinyu Wang1, Gaowei Hu1, Yupeng Shao1

  • 1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infections Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Qidong-Fudan Innovative Institute of Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.

Theranostics
|June 16, 2025
PubMed
概括

这项研究揭示了SUMOylation如何调节SARS-CoV-2尖端蛋白功能,影响病毒传播. 一种新型的抑制剂 (cpSIM2) 显示出对SARS-CoV-2变种的广泛疗效.

关键词:
抗病毒类的抗病毒.这就是SARS-CoV-2病毒.这就是SUMOylation的作用.尖蛋白质是一种尖蛋白质.

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