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基于极地微藻的纳米粒子:用于癌症治疗的下一代策略

Gülcan Ayşin Karaca^1,2, Özgür Cem Erkin³, Benan İnan^1,2

¹Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Davutpasa Campus, Esenler, 34220 Istanbul, Türkiye.

|June 16, 2025

概括

极地微藻产生具有抗癌性能的生物活性黄类. 来自*Auxenochlorella pyrenoidosa*和*Chlorella sorokiniana*的提取物和封装纳米颗粒显示出降低癌细胞活力的潜力,为癌症治疗提供了新的途径.

科学领域:

海洋生物技术海洋生物技术
药理学药理学是指药理学的学科.
癌症研究癌症研究

背景情况:

极地微藻产生生物活性化合物作为恶劣环境中的生存机制.
来自微藻的黄胺具有显著的抗癌活性.
研究极地微藻生物活性提供了新的癌症治疗策略.

研究的目的:

评估极地微藻 *Auxenochlorella pyrenoidosa* (CP) 和 *Chlorella sorokiniana* (CS) 的富含黄酸盐的提取物 (FRME) 的抗癌疗效.
评估封装FRME (FRME-NP) 对人类肺癌 (A-549) 和乳腺癌 (MCF-7) 细胞系的活性.
确定这些微藻衍生化合物作为制药抗癌剂的潜力.

主要方法:

从极地微藻CP和CS中提取黄素.
将富含黄胺的极地微藻提取物封装成纳米粒子 (FRME-NP),并进行尺寸和效率分析.
在体外评估CP和CS提取物和FRME-NP细胞毒性对A-549和MCF-7细胞系在不同度和暴露时间.

主要成果:

黄素含量:CP的QE/gDE为1.16 mg,CS的QE/gDE为0.6 mg.
封装纳米粒子 (FRME-NP) 范围为156-294nm,封装效率为85-92%.
无论是FRME还是FRME-NP,都显示出不同程度的抗癌活性对抗A-549和MCF-7细胞,对抗MCF-7细胞的疗效更高 (约. 在48小时内以100μg/mL的剂量减少60%的活力).
暴露时间的延长与癌细胞活力降低相关.

结论:

极地微藻是抗癌化合物的有希望的来源,特别是黄类.
富含黄胺的提取物及其纳米粒子配方显示出癌症治疗的巨大潜力.
对这些微藻衍生化合物的进一步研究可能会导致用于癌症治疗的新生物技术药物.

关键词:

抗癌活性抗癌活性在C. pyrenoidosa中使用.C. 索罗基尼亚纳纳纳索罗基尼亚纳纳纳米颗粒是如何形成的这是极地微藻.

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