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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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氨酸向疟疾激酶PfCLK3的共价抑制剂Pf

Skye B Brettell1, Gillian Cann2, Abbey Begen2

  • 1School of Chemistry, The Advanced Research Centre, University of Glasgow 11 Chapel Lane Glasgow G11 6EW UK andrew.jamieson.2@glasgow.ac.uk.

RSC medicinal chemistry
|June 16, 2025
PubMed
概括

研究人员开发了新的抗疟疾药物,针对Plasmodium falciparum CLK3 (PfCLK3) 激酶中的必需氨酸残留物. 这些新型的氨酸向性共价抑制剂为克服疟疾治疗中抗药性提供了有希望的策略.

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