较高的HEI-2015得分与帕金森病风险降低有关:一项基于全国人口的全国性研究
Wenting Hu1, Hai Liu2, Ying Zhang3
1Department of Neurology, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu First People's Hospital, Chengdu, Sichuan, China.
Frontiers in nutrition
|June 16, 2025
概括
通过2015年健康饮食指数 (HEI-2015) 衡量,更高质量的饮食与美国成年人患帕金森病 (PD) 的风险降低有关. 改善饮食质量可能是降低PD患病率的关键生活方式因素.
科学领域:
- 营养流行病学 营养流行病学
- 神经退行性疾病 神经退行性疾病
- 公共卫生 营养 公共卫生 营养
背景情况:
- 越来越多的证据将饮食与帕金森病 (PD) 的发展联系在一起.
- 关于美国成年人口的饮食质量和PD风险的研究有限.
- 本研究使用国家数据集调查了饮食质量与PD风险之间的关联.
研究的目的:
- 评估2015年健康饮食指数 (HEI-2015) 评分量化的饮食质量与帕金森病 (PD) 风险之间的关系.
- 检查潜在的值效应和这种关联中的修改因素.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2003-2018) 的数据进行横截面分析.
- 使用HEI-2015评分评估的饮食质量.
- 使用了加权多变量逻辑回归,受限立方线 (RCS) 和两段线性回归模型.
主要成果:
- 总共有29,581名美国成年人 (286名患有PD) 被分析.
- 2015年HEI得分每增加10分,就会降低17%的患PD的可能性 (OR:0.858,p=0.039).
- 较高的HEI-2015分数显示出与PD患病率存在显著的反向关联,观察到的值效应约为55.5 (OR:0.957,p=0.045).
结论:
- 2015年健康饮食指数 (HEI-2015) 与帕金森病 (PD) 患病率有负面关联.
- 饮食质量代表了降低PD风险的潜在可修改因素.
- 研究结果强调了饮食模式在预防神经退行性疾病中的重要性.
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