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Updated: Sep 19, 2025

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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Published on: April 28, 2019

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一个新型大麻素受体1对手的合成和药理学特征

Iker Bengoetxea de Tena1, Gorka Pereira-Castelo1, Jonatan Martínez-Gardeazabal1

  • 1Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa University Campus, Sarriena s/n, 48940, Leioa, Spain.

ACS omega
|June 16, 2025
PubMed
概括

研究人员开发了UVI3502,一种新型CB1受体对抗剂,以解决大麻素受体抑制剂的副作用. 这种化合物为研究内分泌大麻素系统和阻断中枢神经系统大麻素受体提供了一个新的工具.

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Drug-Receptor Interaction: Antagonist

An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
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Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
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Separation of...
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