铜 (II) 和二氧化 (V) 复合物基于抗增殖化剂HDpk44mT:结晶学分析,光谱特征和细胞毒性
Iman K Al Salmi1, Hamad H Al Mamari1, Craig C Robertson2
1Department of Chemistry, College of Science, Sultan Qaboos University, PO Box 36, Al-Khod, 123 Muscat, Sultanate of Oman.
ACS omega
|June 16, 2025
概括
新的铜和二氧化碳复合物显示出抗增殖活性. 二氧化-V复合物对MCF-7癌细胞具有选择性作用,而铜-II复合物缺乏选择性.
科学领域:
- 协调化学 协调化学
- 药用化学 医学化学
- 材料科学 材料科学 材料科学
背景情况:
- 二甲联体是金属复合体的多功能构建模块,具有多种应用.
- 研究新型金属复合物对于开发新的治疗药物至关重要.
研究的目的:
- 为了合成和描述新型的铜 - - - - - - - - - - - - - - - - - - - 和二氧化 - - - - - - - - - - - - - - - - - - - - - - - 复合物,使用一个二 - - - - - - - - - - - - - - - - - - - - - - - - - - - - 皮里迪尔) 基提胺二氧化二氧化碳联体.
- 评估这些复合体对各种癌症细胞系的抗增殖活性.
主要方法:
- 单晶X射线衍射用于结构确定.
- 通过NMR和EPR光谱来阐明溶液结构和电子性质.
- 针对HeLa,MCF-7和MCF-10A细胞系的体外抗增殖试验.
主要成果:
- 确定了水合二二甲基4,4-二甲基-3-二氧化碳 (HDpk44mT·H2O),两个铜-II) 复合物 (1·1-1/2) -MeOH和2) 以及一个二氧化瓦纳-V) 复合物 (3) 的晶体结构.
- 复合物1·1-(1/2)-MeOH和2表现出扭曲的正方形-金字塔协调几何和对HeLa和MCF-7细胞的抗增殖作用,但缺乏选择性.
- 复合体3显示对MCF-7细胞具有选择性和强大的活性,具有扭曲的方形金字塔式中心.
结论:
- 合成的铜和复合物代表了二--2-二基胺二氧化碳衍生物的罕见例子.
- 铜-II) 复合物表现出广泛的抗增殖疗效,但缺乏选择性.
- 二氧化-V复合物显示出有前途的选择性抗癌活性,这需要进一步研究抗瘤应用.
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