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Updated: Sep 19, 2025

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
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Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

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通过可变自编码器的最佳化来阐明蛋白质动力学

Subinoy Adhikari1, Jagannath Mondal1

  • 1Tata Institute of Fundamental Research, Hyderabad 500046, India.

Journal of chemical theory and computation
|June 16, 2025
PubMed
概括

这项研究引入了一种新的方法,使用解释的变异分数 (FVE) 来优化蛋白质动态的变异自编码器 (VAE). 这种方法改善了复杂的蛋白质构造景观的分析.

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This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
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