对结核性水炎的COTS计算器的验证:印度队列中的预测性能和诊断实用性
Janakiraman Palani1, Carlos Cifuentes Gonzalez2,3, Gazal Patnaik1
1Department of Uvea and Ocular Pathology, Sankara Nethralaya, Chennai, India.
Ocular immunology and inflammation
|June 16, 2025
概括
诊断眼结核病 (OTB) 是一个挑战. COTS计算器有助于做出抗结核治疗决策,在高负担地区与其他测试相结合时显示出有前途.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 临床决策支持 临床决策支持
背景情况:
- 眼结核病 (OTB) 的诊断是困难的,因为细菌负载较低,缺乏确定的测试.
- 协作眼部结核病研究 (COTS) 计算器是为了帮助抗结核治疗 (ATT) 决策而开发的.
研究的目的:
- 在南印度群体中对COTS计算器进行外部验证.
- 评估放射学和免疫学测试在OTB诊断中的附加值.
主要方法:
- 对196名OTB患者 (2015-2022) 的回顾性队列研究.
- 评估了两个COTS计算器值 (M4I1,M4I2).
- 评估诊断性能和复合测试成绩 (CT+CXR,TST+IGRA).
主要成果:
- M4I2的值显示了比M4I1 (60%) 更高的灵敏度 (83%),具有可比的AUC.
- 这两个门都有高的正预测值 (PPV),但低的负预测值 (NPV).
- 较高的COTS分数和多次阳性测试与更好的治疗反应相关.
结论:
- COTS计算器 (M4I2) 是指导在OTB中的ATT决策的一个有用工具.
- 与放射学和免疫学测试的整合支持结核病流行环境中的早期治疗.
- 建议对COTS计算器进行前性验证.
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