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Updated: Sep 19, 2025

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

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未定位的DNA吸收学确定了阿里斯托洛希克酸III作为一种强大的DNA破坏剂,在老鼠尿道系统中的11种替代芳香基因毒剂中

Medjda Bellamri, Scott J Walmsley, Lihua Yao

  • 1Department of Pharmacological Science, Stony Brook University, Stony Brook, New York 11794, United States.

Chemical research in toxicology
|June 16, 2025
PubMed
概括

像3-二三 (3-NBA) 和阿里斯托洛基亚酸-I (AA-I) 这样的二在老鼠中形成了丰富的DNA添加物. 一种相关的化合物,AA-III,在尿道系统中显示出独特的高DNA损伤,突出显示了其潜在的癌症风险.

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