一个常见的变化,以努力为基础的决策在冷漠,无情,和晚期昼夜节律的节律
Sara Z Mehrhof1, Camilla L Nord1,2
1MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom.
eLife
|June 16, 2025
概括
在神经精神疾病中,基于努力的决策受损,并受到昼夜节律的影响. 考虑到这些因素对于理解动机缺陷和开发治疗方法至关重要.
科学领域:
- 神经科学是一个神经科学.
- 计算精神病学是一种计算精神病学.
- 心理学 心理学 心理学
背景情况:
- 动机缺陷,如冷漠和无情,在大脑疾病中普遍存在,并且与预后不佳有关.
- 基于努力的决策受损是这些动机缺陷的潜在神经生物学基础,在各种神经精神疾病中观察到.
研究的目的:
- 研究基于努力的决策与神经精神综合征之间的联系.
- 检查昼夜节律对基于努力的决策的影响.
- 评估昼夜节律和测试时间之间对基于努力的决策的相互作用.
主要方法:
- 利用游戏化的在线任务来测量994名参与者的基于努力的决策.
- 采用计算建模和离线验证来测试-重新测试可靠性.
- 进行了两个预先注册的研究,包括跨诊断和诊断标准方法,并测试了早期和晚期昼夜节律的个体.
主要成果:
- 重复的发现将基于努力的决策能力受损与神经精神综合征联系在一起.
- 证明昼夜节律与测试时间相互作用,影响基于努力的决策.
- 昼夜节律对计算精神病学结果的可靠性和解释有重大影响.
结论:
- 基于努力的决策是理解神经精神疾病中的动机障碍的一个关键领域.
- 循环节律是一个关键的,经常被忽视的变量,影响基于努力的决策.
- 未来的研究必须解开神经精神疾病和昼夜节律的影响,以推进动机病理理解和临床干预.
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